The FreeSurfer software pipeline calculates the cortical surface and sulci of every subject using a surface registration method, segments the volumes of subcortical regions, and calculates their volumes in native space without any geometric deformations. Participants with diabetes were required to have glucose levels between 70 and 300 mg/dL within 60 min prior to all scanning sessions.Ĭortical reconstruction and volumetric segmentation were performed with the FreeSurfer image analysis suite, version 5.3 ( ), optimized for longitudinal processing and SA accuracy. A second MRI session was performed on a separate day if the initial scan could not be successfully completed or if image quality was deemed unacceptable after the first attempt. ![]() ![]() By design, two MP-RAGE acquisitions were obtained for all participants to increase the probability that at least one scan would be collected with minimal head motion. Participants were awake and unsedated and had previously received training designed to help them succeed with the motion restriction requirements of MRI. Sagittal T1 images of the brain were acquired using a magnetization-prepared rapid acquisition gradient echo (MP-RAGE) pulse sequence with the following parameters: repetition time 2,300 ms, echo time 2.98 ms, inversion time 900 ms, flip angle 9°, field of view 25.6 × 24 cm, 160 slices, matrix 256 × 256, voxel size 1.0 × 1.0 × 1.0 mm, and duration 4 min 54 seconds. Multisite calibrations were performed by scanning the same two adult human phantoms on every machine to confirm the repeatability of measurements across sites. An identical imaging protocol was uploaded to every scanner. In addition, participants with diabetes had an onset age older than 6 months, and healthy control subjects without diabetes had a glycated hemoglobin (HbA 1c) level of <6.0% (42 mmol/mol) and a fasting blood glucose level of <110 mg/dL (6.1 mmol/L).Īll imaging sites used a Siemens 3T MAGNETOM Trio, a Tim System whole-body MRI system, and a standard 12-channel head coil. ![]() By design, all participants were born at ≥34 weeks of gestation with a birth weight of ≥2,000 g and had no genetic, neurologic, or psychiatric disorders had no intellectual disability or language or learning disability were not enrolled in self-contained special education programs and had no visual or auditory impairments and no contraindications for brain MRI. In brief, children with diabetes ( N = 144) and healthy control subjects without diabetes ( N = 72) between 4 and 10 years of age (mean age at study entry 7.0 years) were recruited for the study, and 210 participants (children with diabetes N = 141, control subjects N = 69) were successfully imaged at both time points. Details of the study participants have been previously reported.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |